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Ultrarapid metabolizers haveduplicate or multiple copies of the entire CYP2D6 gene. They are synthesized locally and the rateof synthesis is governed by the rate of releaseof arachidonic acid from membrane lipids inresponse to appropriate stimuli. Persistent environmental pollutants and couple fecundity:the LIfE study. Suchdisabling dementia develops over a period of manyweeks or months. A releasemechanism for hallucinations is supported by (1) a sensorydeficit in the same modality as unimodal hallucinations,with onset of hallucinations in conjunction with or follow-ing the sensory deficit; (2) variable content; (3) awarenessof the hallucinatory nature of the perception; and (4) no evi-dence of seizures or other irritative phenomena (includingno other positive motor or sensory phenomena, not par-oxysmal in character, no epileptiform discharges on elec-troencephalography, and unresponsive to administrationof anticonvulsant medications) (Cogan, 1973; Lanska et al.,1987a; Lanska and Lanska 1993; Braun et al., 2003; Lanska,2005)

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[31] compared sinus tract samples with intraop-erative bone biopsy and found concordance in only 44% of cases.

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